highlighted publications

Ward EL, Benowitz L, Brunner TM, Bu G, Cayouette M, Canto-Soler V, Da Mesquita S, Di Polo A, DiAntonio A, Duan X, Goldberg JL, He Z, Hu Y, Liddelow SA, La Torre A, Margeta MA, Quintana F, Shekhar K, Stevens B, Temple S, Venkatesh H, Welsbie D, Flanagan JG. Modeling neurodegeneration in the retina and strategies for developing pan-neurodegenerative therapies. Molecular Neurodegeneration. 2025 Oct 14;20(1):108. 

Cullen PF, Xue Y, Margeta MA. An Ex Vivo Explant Model for Studying Glial Interactions in the Mouse Retina. J Vis Exp. 2025 Jul 15;(221).

Xue Y, Margeta MA. "Optic nerve of steel": A case of very high intraocular pressures with markedly little visual field progression over years. Am J Ophthalmol Case Rep. 2025 Apr 8;38:102325. 

Lin JB, El Helwe H, Falah H, Hammerschlag BL, Schultz SA, Baldwin G, Xue Y, Vasan RA, Song C, Lo K, Meeker A, Wang SL, Kivisäkk P, Solá-Del Valle D*, Margeta MA*. Evaluation of Serum and Aqueous Humor Neurofilament Light Chain as Markers of Neurodegeneration in Glaucoma. Transl Vis Sci Technol. 2025 Feb 3;14(2):24. (*co-senior authors)

Lin JB, Harris JM, Baldwin G, Goss D, Margeta MA. Ocular effects of Rho kinase (ROCK) inhibition: A systematic review. Eye (Lond). 2024 Dec;38(18):3418-3428. 

Yin Z, Rosenzweig N, Kleemann KL, Zhang X, Brandão W, Margeta MA, Schroeder C, Sivanathan KN, Silveira S, Gauthier C, Mallah D, Pitts KM, Durao A, Herron S, Shorey H, Cheng Y, Barry JL, Krishnan RK, Wakelin S, Rhee J, Yung A, Aronchik M, Wang C, Jain N, Bao X, Gerrits E, Brouwer N, Deik A, Tenen DG, Ikezu T, Santander NG, McKinsey GL, Baufeld C, Sheppard D, Krasemann S, Nowarski R, Eggen BJL, Clish C, Tanzi RE, Madore C, Arnold TD, Holtzman DM, Butovsky O. APOE4 impairs the microglial response in Alzheimer's disease by inducing TGFβ-mediated checkpoints. Nat Immunol. 2023 Sep 25. 

Lin JB, Pitts KM, El Helwe H, Neeson C, Hall NE, Falah H, Schultz SA, Wang SL, Lo K, Song C, *Margeta MA, *Solá-Del Valle D. Neurofilament Light Chain in Aqueous Humor as a Marker of Neurodegeneration in Glaucoma. Clin Ophthalmol. 2023 Aug 2;17:2209-2217. (*co-senior authors)

Yin Z, Herron S, Silveira S, Kleemann K, Gauthier C, Mallah D, Cheng Y, Margeta MA, Pitts KM, Barry JL, Subramanian A, Shorey H, Brandao W, Durao A, Delpech JC, Madore C, Jedrychowski M, Ajay AK, Murugaiyan G, Hersh SW, Ikezu S, Ikezu T, Butovsky O. Identification of a protective microglial state mediated by miR-155 and interferon-γ signaling in a mouse model of Alzheimer's disease. Nat Neurosci. 2023 Jun 8.

Pitts KM and Margeta MA. Myeloid masquerade: Microglial transcriptional signatures in retinal development and disease. Front Cell Neurosci 2023 Jan 26;17:1106547

Pitts KM, Neeson CE, Hall NE, Lin JB, Falah HK, Wang SL, Lo K, Song C, Margeta MA*, Solá-Del Valle D*. Neurodegeneration markers Galectin-3 and Apolipoprotein E are elevated in the aqueous humor of eyes with glaucoma. Transl Vis Sci Technol, 2022 Nov 1;11(11):1. (*co-senior authors)

Margeta MA, Yin Z, Madore C, Pitts KM, Letcher SM, Tang J, Jiang S, Gauthier CD, Silveira SR, Schroeder CM, Lad EM, Proia AD, Tanzi RE, Holtzman DM, Krasemann S, Chen DF, Butovsky O. APOE4 impairs the response of neurodegenerative microglia and prevents neuronal loss in glaucoma. Immunity. 2022 Sep 13;55(9):1627-1644.e7.

Shi H, Yin Z, Koronyo Y, Fuchs DT, Sheyn J, Davis MR, Wilson JW, Margeta MA, Pitts KM, Herron S, Ikezu S, Ikezu T, Graham SL, Gupta VK, Black KL, Mirzaei M, Butovsky O, Koronyo-Hamaoui M. Regulating microglial miR-155 transcriptional phenotype alleviates Alzheimer's-induced retinal vasculopathy by limiting Clec7a/Galectin-3+ neurodegenerative microglia. Acta Neuropathol Commun. 2022 Sep 8;10(1):136

Lorenzo MM, Devlin J, Saini C, Cho KS, Paschalis EI, Chen DF, Nascimento E Silva R, Chen SH, Margeta MA, Ondeck C, Solá-Del Valle D, Chodosh J, Ciolino JB, Pineda R, Pasquale LR, Shen LQ. The Prevalence of Autoimmune Diseases in Patients with Primary Open-Angle Glaucoma Undergoing Ophthalmic Surgeries. Ophthalmol Glaucoma. 2021 Aug 18:S2589-4196(21)00186-1. 

Margeta MA, Letcher SM, Igo RP, Cooke Bailey JN, Pasquale LR, Haines JL, Butovsky O, Wiggs JL. Association of APOE with primary open angle glaucoma suggests a protective effect for APOE ε4. IOVS, 2020 61(8):3  

Liu WW, Margeta, MA. Imaging retinal ganglion cell death and dysfunction in glaucoma. Int Ophthalmol Clin. 2019 Fall;59:41-54.

Margeta MA, Lad EM, Proia AD. CD163+ macrophages infiltrate axon bundles of postmortem optic nerves with glaucoma. Graefes Arch Clin Exp Ophthalmol 2018 256:2449-2456

Margeta MA, Wang GJ, Shen K. Clathrin adaptor AP-1 complex excludes multiple postsynaptic receptors from axons in C. elegans. Proc Natl Acad Sci USA, 2009 106:1632-7

Colón-Ramos DA, Margeta MA, Shen K.  Glia promote local synaptogenesis through UNC-6 (netrin) signaling in C. elegans. Science 2007 318: 103-6.